Abstract:
Herpes Simplex Virus type 2 (HSV-2) has public health importance as a leading cause of genital ulcers, a co-factor in HIV-1 acquisition and transmission and as a cause of neonatal herpes infections. Little is known of the epidemiology and burden of disease in Coastal Kenya. The objective of this study was to describe the serological prevalence of HSV-2 infection, factors associated with infection and the potential risk for vertical transmission among women aged 15-34 years. Plasma samples of 826 women who participated in an HIV-1 survey in Kilifi in 2004 were screened for HSV-2 IgG antibodies using HerpeSelect ELISA. The sample comprised 563 women selected randomly from a demographic surveillance system (DSS) and 263 women who presented for voluntary counseling and testing (VCT). Predictors for HSV-2 seropositivity and HIV-1/HSV-2 co-infection were determined using multivariate logistic regression. The incidence of maternal HSV-2 infection and risk of neonatal herpes were estimated by a simple catalytic model fitted to age-seroprevalence data. The overall HSV-2 seroprevalence was 36% (296/826), and differed between DSS and VCT recruits (32% vs. 44%, P<0.001). The HIV-1 prevalence was 8% and 12% (P = 0.12) among the DSS and VCT recruits, respectively. Independent risk factors for HSV-2 infection in all women were: older age (30-34 years; odds ratio (OR) 10.5, 95% confidence interval (CI): 5.2 - 21.0), recruitment from VCT (OR 1.5, 95% CI: 1.1 - 2.1), history of genital ulcers (OR 1.7, 95% CI: 1.2 - 2.3) and HIV infection (OR 2.7,
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