Factors associated with Isoniazid preventive therapy among HIV patients attending comprehensive care clinic at Chuka County referral hospital, Kenya

Abstract

Background:Tuberculosis (TB) in humans is caused by bacilli Mycobacterium tuberculosis and Mycobacterium tuberculosis complex. AIDS is an immunodeficiency disease caused by human immunodeficiency virus (HIV) (Mindachew et al., 2014). HIV breaks down the body's defense against infection and immune system by destroying specific white blood cells (CD4 cells) weakening the immune system hence the body cannot fight an illness attack such as tuberculosis (Cook, 2009). Materials and Methods: A descriptive cross sectional study design adopted with the target population being the zero positive patients attending Comprehensive Care Centre (CCC) services at the facility. Systematic random sampling method used as the sampling technique. Data collection was interviewer administered questionnaire and focused group discussion. Quantitative information was be analysed using SPSS version 25. Chi square method used to test the association between dependent and independent variables. Data presented in tables, pie charts, bar graphs and narrations. Results:The study found out that there was a significant association between quality of service by the caregiver and Patients who completed medication on Isoniazid Preventive Therapy. Further results showed that there was insignificant association between sex and compliance with IPT. Results showed that there was a significant association between the marital status and compliance with isoniazid preventive therapy (IPT. The study established that there was significant association between the taking of the IPT drug and reason for taking the drug. Further, the study established that there was significant association between the side effects of the IPT drug and compliance to Isoniazid Preventive Therapy among HIV patients attending CCC at Chuka referral hospital. Findings further found that association between friendliness of the Hospital staff was significant. The study found out that association between waiting time at the Hospital and compliance with IPT was significant. Conclusion:Research showed that association between health education and compliance with IPT was significant. These results were, shared with hospital administration in order to understand factors that contribute to non-adherence to isoniazid preventive therapy, for necessary action to be, taken in order to increase the uptake of isoniazid preventive therapy. These results are, expected to be crucial for HIV/TB collaborative activities in reducing the mortality rate, morbidity rate and mental complications of TB in people living with HIV/AIDS. Key word: Tuberculosis, HIV, Isoniazid, Therapy