Abstract:
A clear and exact quantitative relationship between dose of radiation and mortality in
humans is still not known because of lack of human data thatwould enable to
determine LD50 for humans in total body irradiation. The death rate equation derived
from the “probacent”-probability equation of survival probability was employed in the
author’s previous study to construct the general formula of LD50 as a function of dose
rate and duration of exposure, using an analytical method of least maximum difference
principle. In this study, a computer program of least sum of squares described in the
author’s previous publication is used to construct a formula of LD50. There is a
remarkable agreement among values of computer-program-of-linear-regressionderived,
least-maximum-difference-derived and reported LD50. The results suggest that
the computer program of linear regression seems to be simple, accurate, convenient
and preferable than the previously used least maximum difference principle, and the
formula of LD50 is better fitting the reported data on LD50 in total body irradiation in
humans. The computer program of linear regression described in this study may be
helpful in biomedical research.
