Potential involvement of the immune system in the development of endometriosis

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dc.contributor.author Kyama, Cleophas M
dc.contributor.author Debrock, Sophie
dc.contributor.author Mwenda, Jason M
dc.contributor.author D'Hooghe, Thomas M
dc.date.accessioned 2017-02-06T13:23:14Z
dc.date.available 2017-02-06T13:23:14Z
dc.date.issued 2017-02-06
dc.identifier.uri http://www.rbej.com/content/1/1/123
dc.identifier.uri http://hdl.handle.net/123456789/2600
dc.description.abstract This article presents an overview of immunological factors and their role in the development of endometriosis, with emphasis on inflammatory cytokines, growth and adhesion factors. Although retrograde menstruation is a common phenomenon among women of reproductive age, not all women who have retrograde menstruation develop endometriosis. The development of endometriosis is hypothesised to be a complex process, which may be facilitated by several factors, including the quantity and quality of endometrial cells in peritoneal fluid (PF), increased inflammatory activity in PF, increased endometrial-peritoneal adhesion and angiogenesis, reduced immune surveillance and clearance of endometrial cells, and increased production of autoantibodies against endometrial cells. Potential biomarkers like cytokines and autoantibodies upregulated during development of endometriosis may be useful in the development of a nonsurgical diagnostic tool. Although endometriosis can be treated using hormonal suppression, there is need for non-hormonal drugs, which can inhibit the development of endometriosis and alleviate pain or infertility without inhibition of ovulation. New molecules that modulate immune function in endometriosis should be the targets for future research. en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.relation.ispartofseries Reproductive Biology and Endocrinology;
dc.subject immunological en_US
dc.subject endometriosis en_US
dc.subject inflammatory cytokines en_US
dc.subject retrograde menstruation en_US
dc.subject peritoneal fluid (PF) en_US
dc.subject JKUAT en_US
dc.title Potential involvement of the immune system in the development of endometriosis en_US
dc.type Article en_US

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