Retroviral protease inhibitors (RPIs) such as lopinavir (LP) and saquinavir (SQ) are active against Plasmodium parasites. However, the exact target(s) for these RPIs in the Plasmodium parasites is unknown. We hypothesized ...

The emergence and spread of multidrug resistant Plasmodium falciparum has severely limited therapeutic options for the treatment of malaria. With ever-increasing failure rates associated with chloroquine or sulphadoxine- ...