Browsing by Author "Thuita, John K."

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Pharmacology of DB844, an Orally Active aza Analogue of Pafuramidine, in a Monkey Model of Second Stage Human African Trypanosomiasis

Thuita, John K.; Kagira, John M.; Denton, Cathrine L.....Et al (PLOS, 2017-02-09)

Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite the recent addition of nifurtimox-eflornithine combination therapy (NECT) to WHO Model Lists of Essential Medicines against second ...
Trypanosoma brucei rhodesiense Transmitted by a Single Tsetse Fly Bite in Vervet Monkeys as a Model of Human African Trypanosomiasis

Thuita, John K.; Kagira, John M.; David, Mwangangi; Matovu, Enock; Turner, C. M. R.; Masiga, Daniel (plosntds, 2017-02-08)

We have investigated the pathogenicity of tsetse (Glossina pallidipes)-transmitted cloned strains of Trypanosoma brucei rhodesiense in vervet monkeys. Tsetse flies were confirmed to have mature trypanosome infections by ...

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